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What is Pancreatic cancer? It is a malignant neoplasm of the pancreas
The main causes of Pancreatic Cancer

The main recognized risk factors for pancreatic cancer include the following:


Cause#1

Smoking:Cigarette smoking has a risk ratio of 1.74 with regard to pancreatic cancer; a decade of non-smoking after heavy smoking is associated with a risk ratio of 1.2. leads to pancreatic cancer.


Cause#2

Advanced age(particularly over 60):is one of the cause for pancreatic cancer

Cause#3

Male gender Pancreatic Cancer Cause-Male sex -:The male to female ratio of pancreatic cancer is 1.3:1.

Cause#4

Chronic pancreatitis - Inflammation of the pancreas, usually from excessive alcohol intake or gallstones.Chronic pancreatitis has been linked, but is not known to be causal. The risk of pancreatic cancer in individuals with familial pancreatitis is particularly high.

Cause#5

Diabetes mellitusis both risk factor for pancreatic cancer, and, as noted earlier, new onset diabetes can be an early sign of the disease.

Cause#6

Pancreatic Cancer - Family history, 5–10% of pancreatic cancer patients have a family history of pancreatic cancer. The genes responsible for most of this clustering in families have yet to be identified. Pancreatic cancer has been associated with the following syndromes; autosomal recessive ataxia-telangiectasia and autosomal dominantly inherited mutations in the BRCA2 gene and PALB2 gene, Peutz-Jeghers syndrome due to mutations in the STK11 tumor suppressor gene, hereditary non-polyposis colon cancer (Lynch syndrome), familial adenomatous polyposis, and the familial atypical multiple mole melanoma-pancreatic cancer syndrome (FAMMM-PC) due to mutations in the CDKN2A tumor suppressor gene.

Cause#7

African-American ethnicity:is one of the cause for pancreatic cancer.

Pancreatic Cancer Cause:Alcohol

It is controversial whether alcohol consumption is a risk factor for pancreatic cancer. Drinking alcohol excessively is a major cause of chronic pancreatitis, which in turn predisposes to pancreatic cancer, but "chronic pancreatitis that is due to alcohol doesn't increase risk as much as other types of chronic pancreatitis." Overall, the association is consistently weak and the majority of studies have found no association.

Some studies suggest a relationship,[20] with risk increasing with increasing amount of alcohol intake. Risk is greatest in heavy mostly on the order of four or more drinks per day. But there appears to be no increased risk for people consuming up to 30g of alcohol a day, so most of the U.S. consumes alcohol at a level that "is probably not a risk factor for pancreatic cancer."

Several studies caution that their findings could be due to confounding factors. Even if a link exists, it "could be due to the contents of some alcoholic beverages" other than the alcohol itself. One Dutch study even found that drinkers of white wine had lower risk.

A pooled analysis concluded, "Our findings are consistent with a modest increase in risk of pancreatic cancer with consumption of 30 or more grams of alcohol per day."

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